HLA-DR is an αβ heterodimer, cell surface receptor, each subunit of which contains two extracellular domains, a membrane-spanning domain and a cytoplasmic tail.

Mar 7, 2025 · Antigen presenting cells use HLA-DR molecules to present protein fragments (processed antigen) to T cells, a key event in induction of T cell responses (PLoS One …

HLA-DR refers to a subtype of HLA genes that encode for MHCII molecules, which are responsible for presenting peptides to CD4 receptors and promoting antibody production.

Jul 19, 2025 · HLA-DR functions within the adaptive immune system, which provides long-lasting protection. Its primary role is to present fragments of proteins from outside the cell to …

Determining class II human leukocyte antigens (HLA) to identify potential disease associations or markers for drug hypersensitivity

Dec 20, 2023 · The Hla Dr gene, also known as the human leukocyte antigen (HLA-DR) gene, is an important gene in the major histocompatibility complex (MHC) class II region. This gene …

Here, we demonstrate that intracellular galectin-9 (gal9) in DCs is required for CD4 + T cell activation through its interaction with the HLA-DR alpha- and beta- cytoplasmic domains, as …